| abstract |
Human androgen receptor DNA binding domain (DBD) compounds as therapeutic agents and methods of using them. A compound having the structure of the formula. A is a substituted or unsubstituted aryl or heteroaryl group, D is a substituted or unsubstituted 5- or 6-membered heteroaryl or heterocyclyl group, and E is substituted A compound which is an aryl, heteroaryl, cycloalkyl or heterocyclyl group, which is or is unsubstituted. This compound includes cancer (prostate, breast, ovary, endometrial or bladder cancer), hair loss, acne, hirsutism, ovarian cyst, polycystic ovarian disease, precocious puberty and age-related macular degeneration, Used to treat signs regulated by androgens. Use of compounds for the manufacture of a medicament for modulating AR activity, methods of treatment, and pharmaceutical compositions and commercial packages comprising said compounds. [Selection] Figure 8 |