| abstract |
Kind Code: A1 A composition and method for transmucosal absorption for administering a therapeutic compound, in particular cyclobenzaprine or amitriptyline, the composition comprising a basifying agent in addition to the therapeutic agent. Providing improved methods and compositions for wound healing. The compositions and methods have many surprising pharmacokinetic benefits over oral administration. Also provided are methods of treating fibromyalgia in a human subject. In some embodiments, the present invention provides a composition comprising cyclobenzaprine suitable for transmucosal absorption. In some embodiments, the present invention provides a composition comprising cyclobenzaprine and a basifying agent that is suitable for transmucosal absorption. 【Selection chart】 None |