| abstract |
The present invention provides a complex comprising rifaximin and a complexing agent with improved solubility and stability. A tablet or capsule for pharmaceutical use comprising a complex of rifaximin and a complexing agent, wherein the complexing agent is polyvinyl pyrrolidone (PVP) or cyclodextrin (CD), However, the complexing agent is not hydroxybutenyl cyclodextrin or a derivative thereof, and the complex is in a non-crystalline form, and is improved as compared with a physical mixture of rifaximin and the complexing agent. Said tablets or capsules exhibiting a solubility which is such that the ratio of rifaximin to said complexing agent is in the range from 4: 1 w / w to 1: 2 w / w. Use in treating a bowel related disorder selected from the group consisting of: irritable bowel syndrome, diarrhea, traveler's diarrhea, diarrhea involving microorganisms, Crohn's disease, chronic pancreatitis, pancreatic insufficiency, and / or colitis A pharmaceutical composition comprising the complex for [Selected figure] Figure 1 |