| abstract |
Methods and systems are provided for biphasic iontophoretic transdermal delivery of improved therapeutic agents that prevent overdosage of drugs. The method includes positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly comprises a solution 54 comprising a therapeutic agent 51 that passively diffuses into the skin. The drug dose is delivered from the assembly into the skin using a first current 60 having characteristics, eg, polarity and magnitude, to repel the drug out of the assembly for a first period of time. During the second period, the drug is retained in the assembly using a second current having drug-attracting properties such that delivery of the drug to the skin is minimized. The drug dose may be delivered on demand by input from the patient. Embodiments can be used for delivery of agents that cause adverse effects by unwanted passive diffusion. [Selected figure] Figure 3-1 |