| abstract |
Disclosed herein are DKP microcrystals produced by an improved method that do not irreversibly self assemble into microparticles. The crystallites can be dispersed by spraying and reformed by spray drying into particles having a shell form of spheres. Active agents and excipients can be incorporated into the particles by spray drying a solution containing the ingredients to be incorporated into the microcrystalline diketopiperazine particles. In particular, microcrystalline particle compositions are suitable for pulmonary drug delivery of one or more peptides, proteins, nucleic acid molecules and / or small organic molecules. 【Selection chart】 None |