abstract |
PROBLEM TO BE SOLVED: To provide an intranasal administration vaccine composition effective in naive subjects such as children. SOLUTION: One or more non-live influenza virus antigens selected from the group consisting of split viruses, subunit influenza antigens, and recombinant antigens, one carboxylic acid, one aqueous medium, and one A composition for use as an intranasal administration vaccine, comprising an adjuvant, the composition comprising: a monoglyceride, and wherein the adjuvant comprises one carboxylic acid and one monoglyceride in a ratio of 1: 1, and is contained in the adjuvant One monoglyceride and one carboxylic acid is at most 3% w / v of the vaccine, the vaccine to immunize against influenza in newborn to 18-year-old pediatric subjects to reduce viral shedding Is the composition. [Selected figure] Figure 1 |