| abstract |
The present invention provides acetyl-CoA carboxylase (ACC) variants for producing malonyl-CoA derived compounds comprising fatty acid derivatives, and host cells expressing said ACC variants. A variant biotin carboxyl carrier protein (BCCP) comprising at least one mutation in a specific amino acid sequence, which constructs the multi-subunit enzyme ACC, wherein expression of the variant BCCP corresponds to the corresponding wild Variant biotin carboxyl carrier protein (BCCP) that confers on recombinant cells an increase in the production of malonyl-CoA derived compounds compared to type cells. 【Selection chart】 None |