| abstract |
PROBLEM TO BE SOLVED: To provide a polysaccharide vaccine against staphylococcal infection. The present invention relates to a composition of Staphylococcus deacetylated poly N-acetylated glucosamine (dPNAG). The dPNAG can be isolated from natural sources or can be synthesized de novo. The present invention is also directed to Staphylococcus aureus, S. et al. Use of dPNAG as a vaccine to induce active immunity against infections caused by epidermidis, related coagulase negative Staphylococcus or coagulase positive Staphylococcus, and other organisms with ica (intracellular adhesion) locus. The invention further provides methods used for antibodies directed against dPNAG, in particular for inducing passive immunity against the same level of infection. 【Selection chart】 None |