| abstract |
The present invention provides modified antibody compositions and methods of making and using the same. Kind Code: A1 The present disclosure provides a modified antibody containing a masking moiety (MM) modified antibody or antibody fragment (AB). Such modified antibodies can be further coupled with a cleavable moiety (CM) to provide an activatable antibody (AA), which cleaves, reduces or photolyzes, or otherwise modifies be able to. AA is such that AB becomes more accessible to the target after, for example, cleavage of CM in the presence of an agent capable of cleaving, reducing or photolyzing CM, removal of MM by reduction or photolysis Can exhibit an activatable conformation. The present disclosure further provides methods of making and using such modified and activatable antibodies. 【Selection chart】 None |