| abstract |
The present invention provides novel kinase inhibitors, in particular inhibitors that are therapeutically useful as IRAK4 inhibitors. A compound of formula (I). [Wherein, A, Y, Z , X 1 , X 2 , X 3 , R 1 and R 3 are specific groups. They are useful in the treatment and prevention of diseases or disorders, in particular in their use in diseases or disorders mediated by kinase enzymes, in particular IRAK4 enzymes. 【Selection chart】 None |