abstract |
PROBLEM TO BE SOLVED: To provide novel histone deacetylase inhibitors. A compound of the following formula: or a pharmaceutically acceptable salt thereof. Wherein each R ′ is independently selected from H and QR 1 and each Q is independently selected from CO, CO 2 , NH, S, SO, SO 2 or O, and each R 1 is independently H , C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, aryl, heteroaryl, C 1 -C 10 cycloalkyl, halogen, C 1 -C 10 alkyl aryl, C 1 -C 10 Is selected from alkyl heteroaryl or C 1 -C 10 heterocycloalkyl, each L is independently selected from 5 to 10 membered nitrogen-containing heteroaryl, W is a zinc linking group, and each R 2 is independently hydrogen or C 1 -C 6 alkyl and R 3 is aryl or heteroaryl. 【Selection chart】 None |