| abstract |
The present invention provides the use of horseradish leaf extract for producing microphthalmia-related transcription factor (MITF) gene expression inhibiting compositions. SOLUTION: The horseradish leaf extract of the present invention is produced by extracting horseradish leaf using water, an alcohol, or an alcohol / water mixture as a solvent. The horseradish leaf extract can reduce the production of melanin by suppressing the gene expression of MITF in skin melanocytes. Thereby, it improves the pigmentation of the skin, lightens stains and lightening lentigo. [Selected figure] Figure 1 |