| abstract |
A novel compound capable of reducing HIF prolyl hydroxylase (PHD) enzyme activity and thereby increasing hypoxia inducible factor (HIF) stability and / or activity and / or level, and the compound Provision of the composition containing. A nicotinamide derivative represented by the following formula: The compounds are useful in PHD inhibitors, pharmaceutical compositions thereof, and methods of treating medical conditions associated with HIF. (R 3 is H, hydroxyl, amino, alkylamino, cyano, halogen, alkyl etc .; R 4 is H, cyano, halogen, methyl, ethyl, trifluoromethyl etc .; R 5 is substituted / unsubstituted phenyl, pyridonyl etc. R 8 is H, halogen, alkyl or the like; R 9 is H, alkyl or cycloalkyl substituted with F 1 to 3; q and s are each independently an integer of 0 to 2) 【Selection chart】 None |