abstract |
The present invention provides a method of treating stage IIIb-IV melanoma. SOLUTION: A herpes simplex virus which has a functional ICP34.5 gene deleted, a functional ICP47 gene deleted, and a gene encoding human GM-CSF, and an anticytotoxic T-lymphocyte related antigen 4 (CTLA-). 4) combination therapy with immune checkpoint inhibitors such as antibodies. 【Selection chart】 None |