| abstract |
The present invention relates to novel crystalline forms, solvates and their crystalline forms of 6-((6,7-dimethoxyquinazolin-4-yl) oxy) -N, 2-dimethylbenzofuran-3-carboxamide. Provided are pharmaceutical compositions comprising them, as well as methods for their preparation. SOLUTION: 6-((6,7-dimethoxyquinazolin-4-yl) oxy) -N, 2-dimethylbenzofuran-3-carboxamide is mixed with at least one dissolving solvent or dissolving solvent mixture and then heated under reflux. A solution is obtained and the solution obtained is slowly cooled to ambient temperature and isolated to form I of 6-((6,7-dimethoxyquinazolin-4-yl) oxy) -N, 2-dimethylbenzofuran-3-carboxamide Obtaining a solid, and drying the resulting solid. 【Selection chart】 None |