abstract |
PROBLEM TO BE SOLVED: To provide a novel free acid polymorphic crystal of SGLT2 inhibitor which has a sodium-dependent glucose transporter (SGLT2) inhibitory action in the intestine and kidney of a mammal and is useful for treating diabetes, diabetic complications, etc. Methods and provision of pharmaceutical compositions containing said crystals. SOLUTION: The crystal of compound I represented by the following formula, wherein ethylene glycol (EG) crystal (SB-1 type), ethylene glycol (EG) crystal (SB-2 type), 1: 2 L-proline A crystal selected from the group consisting of crystals (form 3), 1: 1 L-proline crystals (type 6), and 1: 1 L-proline hemihydrate crystals (type H.5-2). 【Selection chart】 None |