| abstract |
The present invention provides a nucleic acid aptamer that specifically binds to factor H, a method for producing the same, and in particular, a method for producing factor H and a method for using the same. SOLUTION: A mixture or collection of nucleic acids is prepared, and (b) a mixture of nucleic acids prepared in step (a), or step (d) when step (b) is repeated. Contacting the mixture of nucleic acids prepared in step (c) (i) with the purified factor H under conditions that a complex can be formed between (i) the nucleic acid of the above mixture and (ii) purified factor H; The nucleic acid complexed with H and (ii) the nucleic acid not complexed with factor H are separated, the nucleic acid complexed with factor H is recovered, and (d) complexed with factor H A method of propagating the formed nucleic acids to obtain a mixture or collection of nucleic acids that bind to factor H and collecting the nucleic acids bound to factor H. 【Selection chart】 None |