| abstract |
The present invention provides compounds and methods of use. The present disclosure provides compounds and compositions for treating diseases or disorders associated with excessive transforming growth factor beta (TGFβ) activity, and methods of using these compounds and compositions. The present disclosure also provides methods of using the present compounds in combination with one or more cancer immunotherapeutics. In addition to the compounds specifically exemplified, any and all stereoisomers, including geometric isomers (cis / trans or E / Z isomers), tautomers, salts, N-oxides, and solvates of the compounds. Applicants also intend to include isomers, and such alternatives may also be used in the disclosed method. 【Selection chart】 None |