| abstract |
The present invention provides a process for preparing an ASK1 inhibitor. A process of preparing a compound of formula (A) which exhibits apoptotic signal-regulated kinase (ASK1) inhibitory activity and is therefore useful in the treatment of diseases such as renal disease, diabetic nephropathy and renal fibrosis. Also provided are compounds that are synthetic intermediates. The compound of formula (A) is 5- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4-isopropyl-4H-1,2,4-triazol-3-yl) pyridine -2-yl) -2-fluoro-4-methylbenzamide. [Selected figure] Figure 1 |