| abstract |
The present invention provides a heterodimeric antibody FC-containing protein such as a bispecific antibody, a medicament containing the same, and a method for producing such a protein. SOLUTION: The first polypeptide comprising an immunoglobulin first Fc region comprises a first Fc region comprising a first CH3 region, and the second Fc region comprises a second CH3 region. A heterodimeric protein comprising a second polypeptide comprising a second Fc region of a globulin, the sequences of the first and second CH3 regions being different, and the first CH3 region and the second CH3 being different The first homodimeric protein has a specific amino acid sequence and the heterodimeric interaction with the domain is stronger than each of the homodimeric interactions of the first CH3 domain and the second CH3 domain. Heterodimeric proteins with amino acid substitutions at 【Selection chart】 None |