| abstract |
The present invention provides additional methods and compositions for capsaicin and other TRPV1 agonist administrations. Kind Code: A1 A composition comprising a TRPV1 agonist such as capsaicin and a solvent system is provided. Topical application of the present compositions results in rapid delivery of the agonist to the skin and epithelium. Also provided are methods of using the compositions for the reduction of nociceptive nerve fiber function in a subject and treatment of capsaicin responsive conditions. The present invention is a method of delivering a TRPV1 agonist to the epidermis and dermis under a 1 cm 2 area of the skin or mucosal surface of a mammal, said area comprising a TRPV1 agonist and at least one penetration enhancer Contacting the at least about 3 nanomoles of the TRPV1 agonist after 30 minutes of the contacting step, wherein the TRPV1 agonist is retained in the epidermis and the dermis. 【Selection chart】 None |