| abstract |
[PROBLEMS] To provide a pH-sensitive liposome capable of shifting the zeta potential of the liposome from positive to negative under arbitrary pH conditions within a predetermined range by adjusting the content ratio of specific components constituting the liposome. do. A phospholipid, a steroid, an anionic substance, and a zwitterionic substance are contained as membrane constituents, and the anionic substance is contained in an amount of 0 to 20% by mass based on the total membrane constituents, and the above It is characterized by containing 5 to 20% by mass of an amphoteric substance. When dispersed in an aqueous medium with the following pH conditions, the zeta potential of the liposomes is positive at pH 5 or lower, negative at pH 8 or higher, and increases in pH value between pH 5 and 8. It was made to shift from plus to minus together. [Selection figure] None |