abstract |
A serine / threonine kinase inhibitor is provided. A compound having Formula I, wherein R 1 , X 1 , X 2 , X 3 and X 4 are inhibitors of ERK kinase, as defined herein. Also disclosed are compositions and methods for treating hyperproliferative disorders. The present invention also relates to a method of inhibiting ERK protein kinase activity in a cell comprising treating the cell with an amount of a compound according to Formula I effective to attenuate or eliminate ERK kinase activity. The invention also relates to a pharmaceutical composition comprising a compound according to formula I and at least one pharmaceutically acceptable carrier, diluent or excipient. [Selection figure] None |