| abstract |
The present invention provides a composition and method for improving the safety of blood-brain barrier receptor-mediated blood-brain barrier transport when treating neurological disorders and the like. A method of transporting a compound across the blood brain barrier, wherein the antibody coupled to the blood brain barrier receptor with low affinity is coupled to the compound and exposed to the blood brain barrier; A method wherein the antibody comprises transporting a compound coupled to the antibody across the blood brain barrier, reducing or eliminating a decrease in red blood cell levels upon administration of the antibody. [Selection figure] None |