| abstract |
Provided are compositions and methods involved in tumor suppression and inhibition of cell infection by pathogens. The composition includes an mRNA cargo that can provide a therapeutic benefit after being introduced into epithelial cells. The mRNA can encode a polypeptide. The polypeptide can suppress epithelial cell proliferation. In other embodiments, the polypeptide may be involved in innate immunity. In various embodiments, the polypeptide may comprise cathelicidin antibacterial protein (CAMP), calprotectin, S100A8, S100A9, β-defensin, S100A7, secretory leukocyte inhibitor, lipocalin 2, or lysozyme. In some embodiments, the mRNA can include a stabilizing moiety such as, for example, a 5 ′ cap or a 3 ′ extension. [Selection figure] None |