| abstract |
The present invention provides a γ-diketone or an analog thereof that activates Wnt / β-catenin signaling and treats or prevents a disease associated with signaling. A compound of formula I or a pharmaceutically acceptable salt thereof. [A ring is a 7-12 membered heteroaryl and the carbon atom on the ring is attached to the carbonyl carbon; the B ring is selected from the group consisting of phenyl and 5-6 membered heteroaryl, The carbon atom is bonded to the carbonyl carbon; R1 is a substituent bonded to the A ring, and each occurrence of H is independently H, unsubstituted C1-C6 alkyl, etc .; R2 is bonded to the B ring Substituent, each time it appears independently, H, unsubstituted C1-C6 alkyl, etc.] [Selection figure] None |