| abstract |
A human PAC1 antibody is provided. Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments thereof, vectors encoding them, and cells are also provided. The antibodies and antigen-binding fragments thereof can inhibit the binding of PAC1 to PACAP and are useful for several PAC1-related disorders, including the treatment and / or prevention of headache disorders, including migraine and cluster headache. is there. The antibody of the present invention contains the sequences described in Table 4A and the like in the light chain CDR and heavy chain CDR. [Selection] Figure 2 |