| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76b4ee3ab4bec7400b850e2334572b4d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-842
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-822
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-645
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2291
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2295
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C31-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-02 |
| filingDate |
2018-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_863658ed38b314f3ae0fba282f45ebce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46c3c57b1e41bd20fb9af402eedc917a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a315a1b88220864d9966a376ac16d265 |
| publicationDate |
2019-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2019023181-A |
| titleOfInvention |
Improved method for the preparation of chiral 3-amino-piperidines, useful intermediates for the preparation of tofacitinib |
| abstract |
A method for preparing (3R, 4R) -1-benzyl-4-methylpiperidin-3-amine is provided. A compound of formula (III) By asymmetric hydrogenation in 2,2,2-trifluoroethanol or methanol solvent in the presence of Rh (I) complex and optically active ferrocenylphosphine. Method for preparing 4-methylpiperidin-3-amine. [Selection figure] None |
| priorityDate |
2017-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |