| abstract |
An object of the present invention is to provide an inhibitor of a fibroblast growth factor receptor. Inhibitors of FGFR-4, pharmaceutical compositions comprising the compounds, and methods of using the compounds and the compositions are described herein. The compounds disclosed herein can form a covalent bond with FGFR4 protein, for example, the compound can form a covalent bond with a cysteine residue of FGFR4, such as, for example, cysteine at residue 552. it can. FGFR1-3 do not contain this cysteine. Thus, the ability to form a covalent bond between a compound and FGFR4 is an important factor in the selectivity of the compounds disclosed herein with respect to FGFR4. [Selection figure] None |