| abstract |
To provide a non-human transgenic animal that develops a tumor. A non-human transgenic animal comprising in its genome a nucleic acid encoding human ARCAP operably linked to a liver-specific promoter. The transgenic animal expresses human ARCAP protein and develops liver, spleen, abdomen, or lymph tumors. Also provided are cell lines derived from non-human transgenic animals that express the human ARCAP gene. Further, by microinjecting a fertilized mouse oocyte with a vector comprising a human ARCAP cDNA operably linked to a liver-specific promoter, and transplanting the microinjected mouse oocyte into a foster mouse, Methods are provided for producing transgenic mice. [Selection figure] None |