abstract |
A highly permeable composition or a highly permeable prodrug of a peptide or peptide-related compound is provided. A highly permeable composition of a peptide or peptide-related compound, comprising (a) a functional unit, (b) a linker, and (c) a transport unit, wherein the functional unit is transferred to the transport unit via the linker. Covalently bonded, the functional unit includes a peptide or peptide-related compound moiety, the transport unit includes a protonatable amine group, and the linker is cleaved after the hyperpermeable composition crosses one or more biological barriers. A highly permeable composition comprising a chemical bond that is capable of [Selection figure] None |