| abstract |
The present invention relates to antibody-based molecules (single domain antibody fragments, scFv molecules, antibodies, antibody fragments, diabodies, and their epitopes) capable of immunospecifically and selectively binding to the {p} Ser 404 epitope of tau (Including the binding domain). Such antibody-based molecules, particularly with the diagnosis and / or treatment of Alzheimer's disease or other tau disorders, detect pathological tau protein conformers when present in a biological sample. Are useful as diagnostic agents for Alzheimer's disease and other tau pathologies. Molecules based on the antibodies of the invention have particular utility as diagnostic markers for Alzheimer's disease and related tau disorders, and as pharmaceutical compositions for the treatment of such conditions. |