http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018535213-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-515 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 |
| filingDate | 2016-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2018535213-A |
| titleOfInvention | Prevention of N-terminal truncation in IgG light chain |
| abstract | The inventors have discovered that a recombinant antibody light chain with a mouse secretory leader sequence and an N-terminal SYE motif is cleaved during post-translational processing. The present disclosure provides two protein engineering solutions: changing the LcN-terminal SYE amino acid sequence to another alternative, or changing the secretory leader peptide sequence. The inventors have shown that both of these solutions are effective in preventing N-terminal light chain cleavage. |
| priorityDate | 2015-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.