| abstract |
The present disclosure relates to the formula [3-((1S, 3R) -1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate- (S) -3′-methyl-2 ′-(pentanoyl { 2 ″-(tetrazol-5-ylate) biphenyl-4′-ylmethyl} amino) butyrate] 6 · XCa 2 + · YNa + · ZH 2 O, wherein X = 1 to 3, Y = 12-16, Z = 9-18, and 2X + Y = 18, [Chemical 1] A complex represented by: Also disclosed are methods for preparing the conjugates and methods for treating chronic heart disease using agents comprising the conjugates. |