abstract |
The present invention provides a process for preparing an enteric coated lyosphere comprising a therapeutic agent comprising: a) a lyosphere comprising the therapeutic agent; b) the lyosphere. Coating with an enteric polymer coating composition; c) providing a step comprising isolating the enteric coated lyosphere. In other embodiments, the present invention provides a dosage form comprising a lyosphere comprising an effective amount of a therapeutic agent and an enteric polymer coating. In some embodiments, the therapeutic agent in this step or dosage form is a polypeptide, protein, peptide, lipopeptide, glycoprotein, fusion protein, protein complex, cytokine, enzyme, antibody, oligonucleotide, vaccine vector, Small molecules, live viruses, inactivated viruses, virus-like particles, viral protein subunits, adjuvants, microbiomes, prebiotics, probiotics or ectobiotics. In some embodiments of the invention, after oral administration, a dosage form containing an enteric-coated lyosphere delivers the therapeutic agent to the ileum, ileum-cecum junction, colon or combinations thereof in a subject. Provide a method. [Selection] Figure 1A |