| abstract |
The present invention relates to novel peptides which impair PBX-dependent control of gene transcription and thus have utility in the treatment or prevention of disorders in which abnormal cell division occurs. In particular, the invention relates to amino acid sequences (I): Y 1 x 1 x 2 KW x 3 x 4 x 5 x 6 x 7 Y 2 (I) Providing a peptide comprising Here, the sequences X 1 to X 7 are amino acid sequences comprising at least 7 amino acids (optionally, 1 or 2 between one or more of the 9 amino acid positions defined herein) Can be interrupted by amino acid residues); X 1 is selected from W, T, PE, KQI, VV, PQT, H, RI and absent; X 2 is an amino acid having an aromatic side chain or cysteine; X 3 is a hydrophobic amino acid and X 4 is an amino acid having a charged side chain; X 5 is an amino acid having a basic side chain; X 6 is amino acid or absent; X 7 is one or more amino acids or absent; and Y 1 and Y 2 are cationic or absent amino acids, provided that at least one of Y 1 and Y 2 is present respectively It is a peptide containing a polymer. |