| abstract |
Disclosed herein are compositions and nanoconjugates comprising micelle constructs, antibody single chain variable fragments (scFv), NF-kb inhibitors, and topoisomerase II inhibitors. Linking a drug molecule to a targeted micelle comprising a micelle construct and an antibody single chain variable fragment (scFv); and delivering the drug molecule conjugated to the targeted micelle to a tumor site by intracellular delivery Further disclosed herein are methods of delivering drug molecules to the tumor site. Administering a therapeutically effective dose of a composition comprising a micelle construct, an antibody single chain variable fragment (scFv), an NF-kb inhibitor, and a topoisomerase II inhibitor to a subject in need thereof. Also disclosed herein are methods of treating or inhibiting tumor cell growth. |