| abstract |
Disclosed herein are Htt repressors and methods and compositions for using Htt repressors. Disclosed herein are methods and compositions for diagnosing, preventing, and / or treating Huntington's disease. In particular, provided herein are methods and compositions for modifying (eg, modulating its expression) HD Htt alleles for the treatment of Huntington's disease, including Htt repressors (which suppress Htt expression). The compositions (Htt repressors) described herein can provide therapeutic benefits to a subject, for example, by reducing cell death, reducing apoptosis, increasing cellular function (metabolism), and / or reducing dysmotility in a subject. give. [Selection] Figure 8 |