| abstract |
The pharmaceutical composition comprises a taxane (eg, paclitaxel, docetaxel, cabazitaxel, larotaxel, otataxel and / or tesetaxel) in a mixture of a first surfactant and a second surfactant. The increase in taxane absorption from the pharmaceutical composition is greater than the sum of docetaxel absorption from either the first surfactant or the second surfactant. Of the absorption when the ratio of the first surfactant to the second surfactant in the pharmaceutical composition is 60:40 to 85:15 and the total surfactant weight does not exceed 98% of the total weight. The increase is particularly enhanced. Polysorbate 80, polysorbate 20, and caprylcaproyl polyoxyglyceride serve as suitable first surfactants, and polysorbate 80 or polyethoxylated castor oil serves as a suitable second surfactant. The stability of the pharmaceutical composition can be further enhanced by including a stabilizer (eg, citric acid and / or ascorbic acid). |