| abstract |
A series of substituted pyrido [3,2-d] pyrimidine and 1,5-naphthyridine derivatives of formula (I) as defined herein, which are selective inhibitors of phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity Is useful for the treatment and / or prevention of a variety of human diseases, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection. |