| abstract |
Methods are provided for preparing exosomes or exosome-like vesicles packaged with a nucleic acid of interest. In certain embodiments, the method can include introducing a nucleic acid construct comprising a nucleic acid sequence of interest incorporated into a pre-miR-451 structural mimetic into an exosome-producing cell, causing the cell to produce an exosome. . Nucleic acid constructs, compositions and uses thereof are also provided. [Selection figure] None |