| abstract |
A method of treating sarcoma by administering a tyrosine kinase inhibitor and a biguanide compound. Ewing sarcoma family of tumors by obtaining a tumor sample, determining the gene expression level of ACTB, B2M, MLH1, PRKDC, XPC, APEX1, ERCC5, MMS19 or RAD23 in the sample and administering a tyrosine kinase inhibitor and a biguanide compound A method of treating is also described. Further disclosed are pharmaceutical compositions for treating Ewing family tumors. The composition contains a tyrosine kinase inhibitor, a biguanide compound, and a pharmaceutically acceptable excipient. [Selection] Figure 4A |