abstract |
The present invention relates to synthetic peptide compounds and complement-mediated diseases such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases such as cystic fibrosis and various acute diseases. Provide its use for therapy and diagnosis. The present invention relates to the modification of a 15 amino acid synthetic peptide from a Polar Associate (PA) peptide, a scrambled peptide derived from a human astrovirus protein. In some embodiments, the present invention provides for peptide mimetics, peptide analogs and / or synthetic derivatives of PA (eg, sarcosine) having modifications including, for example, internal peptide substitutions, and PEGylation at the N-terminus and C-terminus. Derivative). The present invention further provides a method of selecting at least one synthetic peptide for treating various conditions. [Selection] Figure 26C |