http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018524322-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C47-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-64 |
| filingDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2018524322-A |
| titleOfInvention | Two-step process for the preparation of 3-substituted phenylalkylamines |
| abstract | Process for producing 3-substituted phenylalkylamines comprising reacting a phenylboronic acid compound with an α-β unsaturated carbonyl-containing compound by asymmetric 1,4-addition reaction followed by reductive alkylation . This process may be useful in the synthesis of tapentadol. One aspect of the present invention includes a process for making a compound of formula (III). This process involves contacting a compound of formula (I) with a compound of formula (IV) to form a compound of formula (II) in the presence of a transition metal catalyst and a chiral ligand. The process further comprises contacting the compound of formula (II) with a secondary amine having formula (V) to form a compound of formula (III). [Selection figure] None |
| priorityDate | 2015-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 493.