| abstract |
The present disclosure provides a GITRL fusion polypeptide subunit comprising a human IgG Fc domain, a trimerization domain, and a receptor binding domain of a GITR ligand, wherein the fusion polypeptide subunit is a hexameric protein Can be self-organized. Also provided are methods of preparing fusion polypeptide subunits and hexameric proteins, and methods of use, eg, methods of treating cancer. [Selection] Figure 1 |