| abstract |
The present invention relates to a compound of formula (I) wherein R1 is hydrogen, F or Cl; L is a bond or lower alkylene; R2 is — (CH2) nO-lower alkyl, by halogen Substituted lower alkyl,-(CH2) nC (O) O-lower alkyl, lower alkyl or phenyl substituted by halogen, or selected from pyridinyl, pyrimidinyl, pyridazinyl, thiazolyl, imidazolyl, pyrazolyl or triazolyl 5 or 6 membered heteroaryl groups, which are optionally lower alkyl, halogen, lower alkoxy, ═O, benzyloxy, cycloalkyloxy, hydroxy, cyano, halogen substituted lower alkyl Or substituted by-(CH2) nO-lower alkyl N is 1, 2, or 3; R3 is hydrogen, lower alkyl, or-(CH2) nO-lower alkyl; R4 is phenyl, pyridinyl, or optionally substituted by F; Pyrimidinyl; Y is CF or CCl) or a pharmaceutically acceptable salt or acid addition salt thereof, a racemic mixture, or a corresponding enantiomer and / or optical isomer and / or stereoisomer thereof About the body. The compounds can be used to treat Parkinson's disease, anxiety, vomiting, obsessive compulsive disorder, autism, neuroprotection, cancer, depression, and type 2 diabetes. |