| abstract |
The present invention relates to the field of chemicals, in particular to purinyl-N-hydroxy pyrimidine formamide derivatives, processes for their preparation and their use. The present invention provides purinyl-N-hydroxy pyrimidine formamide derivatives having the structure shown in Formula I. The present invention provides a process for the preparation of said purinyl-N-hydroxy pyrimidine formamide derivatives and their use. The purinyl-N-hydroxy pyrimidine formamide derivatives provided by the present invention can not only be kinase inhibitors with PI3K and HDAC bifunctional targets, but also kinase inhibitors with PI3K or HDAC single functional targets. It thus provides a new option for preparing multitargeted inhibitors. [Chemical formula 1] |