| abstract |
A series of substituted 3,4-dihydro-2H-1,4-benzoxazin-3-one derivatives, which are potent modulators of human TNFα activity, are therefore autoimmune and inflammatory diseases; neurological and neurodegenerative diseases Pain and nociceptive diseases; cardiovascular diseases; metabolic disorders; ocular diseases; and oncological diseases are beneficial in the treatment and / or prevention of various human diseases. |