http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018520111-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2018520111-A |
| titleOfInvention | Nucleoside agents for reducing the detrimental activity of extended nucleotide repeats containing genes |
| abstract | Embodiments of the present invention provide for the detrimental activity of mutated extended nucleotide repeats (NR) containing intracellular target genes by contacting the cells with an effective amount of a nucleoside agent, as well as compositions used in such methods. Including a method of reducing. The detrimental activity (eg, toxicity and / or dysfunction of the product encoded thereby) of the mutated extended NR containing the target gene can be determined by different methods, eg, the toxic expression product encoded by the target gene. May be reduced by reducing production (eg, RNA or protein) or activity (and, in some cases, differentially including selection). Kits and compositions for carrying out the methods are also provided. |
| priorityDate | 2015-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 648.