| abstract |
Provided are compounds according to formula (I) and pharmaceutically acceptable salts thereof and pharmaceutical compositions thereof, wherein R 1, R 2, R 3, R 6, R 7, R 8 and n are as defined herein. As defined in The compounds of the invention are expected to be useful for the prevention and treatment of various conditions. Provided herein are substituted oxysterols useful for the prevention and / or treatment of a wide range of disorders, including but not limited to NMDA-mediated disorders. These compounds are expected to exhibit improved in vivo potency, pharmacokinetic (PK) properties, oral bioavailability, formulation suitability, stability and / or safety as compared to other oxysterols. Further provided are pharmaceutical compositions comprising the compounds of the invention and methods of their use and treatment. |